New Therapeutic Approaches to Chronic Kidney Disease
نویسندگان
چکیده
منابع مشابه
Chronic kidney disease - new approaches to classification
4 0 6 • H O S P I TA L P H A R M AC I S T Over the past few years the terminology used to describe kidney disease has changed. Previously, as the kidneys became less and less able to do their normal work of cleaning the blood and producing urine from the waste products, patients were said to have chronic renal or kidney failure. The term “end stage renal failure”was used to describe those patie...
متن کاملNew Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease
In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondria...
متن کاملMitochondria: a new therapeutic target in chronic kidney disease
Cellular metabolic changes during chronic kidney disease (CKD) may induce higher production of oxygen radicals that play a significant role in the progression of renal damage and in the onset of important comorbidities. This condition seems to be in part related to dysfunctional mitochondria that cause an increased electron "leakage" from the respiratory chain during oxidative phosphorylation w...
متن کاملNew treatment approaches in chronic kidney disease-associated anaemia.
INTRODUCTION Erythropoiesis-stimulating agents (ESA) and iron are the main tools for treating anaemia associated with chronic kidney disease (CKD). Pharmaceutical research has focused on modified epoetins or different strategies to stimulate erythropoiesis with the idea of improving relative disadvantages of the molecules already available in the market. AREAS COVERED Following a literature s...
متن کاملPolycystic kidney disease and therapeutic approaches.
Polycystic kidney disease (PKD) is a common genetic disorder in which extensive epithelial-lined cysts develop in the kidneys. In previous studies, abnormalities of polycystin protein and its interacting proteins, as well as primary cilia, have been suggested to play critical roles in the development of renal cysts. However, although several therapeutic targets for PKD have been suggested, no e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Comparative Pathology
سال: 2018
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2017.10.098